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The absence of human safety data means the full range of potential harms is, by definition, unknown — and the gray-market products circulating as "research chemicals" are not manufactured under pharmaceutical standards

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¹⁸ Real-world dosing and outcomes — the spread is mostly a denominator and achieved-dose story: six-month persisters lose about 12–13% (Hankosky), a broad cohort about 9.8% (Adamidis), and selected telehealth completers near 23% (Duncan)