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Originally identified by Loren Pickart in human plasma, GHK-Cu has been the subject of extensive cellular biology and biochemical research literature for over five decades, with research contexts examining tissue biology, cellular signaling pathways, copper-binding peptide chemistry, and extracellular matrix research

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This review provides a comprehensive and up-to-date synthesis of kale’s botanical characteristics, cultivation practices, chemical constituents, biological activities, and applications in pharmacy, functional foods, and cosmetics