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Notably, combination treatment induced a higher polyfunctionality of CAR-T cells with increased cytokine composition of co-secreting IFN-γ, granzyme B, and perforin, etc., at single-cell level in vitro compared with each treatment (Supplemental Figure 7, C and D) and enabled improvement of antitumor activity of CAR-T cells in NOD scid gamma (NSG) mice bearing HCC-1806 tumors (Figure 4, T and U)

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The presentation, documentation and lot tracking are structured to align with laboratory routines that require sterile handling, consistent records and specification sheets accompanying each unit