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In laboratory and small clinical studies, GHK-Cu has been associated with changes in genes involved in tissue remodeling, antioxidant defense, and how skin responds to damage

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Additionally, mitragynine (10 μ M) inhibited digoxin transport in Caco-2 cell monolayers to the same extent as the clinically relevant P-gp inhibitor quinidine (Rusli et al., 2019)

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