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Furthermore, low levels of BDNF inhibit the effective translocation of Nrf2 to the nucleus, impairing Nrf2 pathway functionality and limiting the activation of antioxidant mechanisms, ultimately resulting in persistent oxidative stress (Bouvier et al., 2017)

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The recent experiments by Christie and Jahr (2008 , 2009) question the interpretation of these results, suggesting that the observed effects could be mediated by NMDA receptors located in the somatodendritic compartment of the presynaptic neuron