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Our hypothesis suggests that future research endeavors will further elucidate the stabilization mechanisms of HIF-1α under hypoxic conditions and its precise regulatory interactions with downstream genes, identifying the specific structural domains involved in HIF-1α’s binding to diverse target genes, thereby providing a theoretical foundation for the design and synthesis of small-molecule HIF-1α inhibitors with enhanced specificity and affinity

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Glucose transporters in cardiac metabolism and hypertrophy