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It is well established that SLC7A11 inhibits ferroptosis through importing cystine, promoting GSH biosynthesis, and subsequently facilitating GPX4-mediated detoxification of lipid peroxides (Fig

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Conversely, the glutamate-bound GluK2 K676C/N802C structures represent shallow- and deep- desensitized conformations as well as an intermediate state between these two desensitized states