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In the active structure of β 2 AR, the portions of TM3 and TM5 on the intracellular side of the receptor form extensive contacts with G s α-helix 5, and TM6 interacts with the nonhelical C-terminal loop of G s α (Figure 3e)

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Supplementary information The online version contains supplementary material available at 10.1038/s41467-023-39901-8