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Patients frequently experience spontaneous pain and heightened tenderness in affected areas, even with minimal pressure.19 This increased perception of pain – often described as a constant, throbbing sensation – is thought to be linked to local inflammatory processes and possible micro-neuropathic changes within the subcutaneous tissue, leading to dysregulation of local-regional sensory nerve fibers.12 Edema and microvascular abnormalities Non-pitting edema is another common manifestation, particularly as the disease progresses, which can be primarily due to an underlying chronic venous disease

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Size:200 Capsule

In a specific embodiment, the nucleic acid sequences are directly administered in vivo, where it is expressed to produce the encoded product