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Reality: L-ascorbic acid needs a pH near 2.5 to 3.5, and at that pH copper can break away from the GHK complex

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The patients were eligible to enter the study if the following inclusion criteria were met: male or female patient between 18 and 75 years of age (limits included) affected by PDN manifesting with distally distributed neuropathic pain (the diagnosis of neuropathy was based on a structured clinical examination)