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Despite the widespread use of validated tools, such as the Gastrointestinal Symptom Rating Scale (GSRS) and Gastroparesis Cardinal Symptom Index (GCSI), the diagnosis of DGE remains hindered by the lack of specific biomarkers and the reliance on exclusion criteria, resulting in high rates of underdiagnosis and clinical oversight (Revicki et al., 2003

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The endeavor to unveil the role of the phosphatidylinositol 3-kinase delta (PI3Kδ) pathway in pSS showed that this pathway was activated in human salivary gland in pSS patients as well as in a mouse model of focal sialadenitis [80]