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A recent study, which monitored the cancer-modulating properties of hot water extracts of fermented and unfermented rooibos in a liver carcinogenesis model against fumonisin B 1 (FB 1 ) promotion in male Fischer rat using diethylnitrosamine as cancer initiator, showed that unfermented rooibos was more protective against FB 1 -induced cancer promotion, by significantly reducing the total number and size of pre-neoplastic foci staining positively for the placental form of γ-glutamyl transferase in the liver, presumably by arresting their growth [270]

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Hence, for the 3243G mutation, the mtDNA copy number appears to partially compensate for the mtDNA defect