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In VRK2-WT cells, as expected, most of SLC7A11 was redistributed to the ER after 1 h of BFA treatment, while at 4 h after BFA removal, almost all the cells showed co-localization of SLC7A11 and the Golgi marker Golgin-97

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Epithalon induces decondensation of heterochromatin, particularly pericentromeric structural heterochromatin, releasing genes that become repressed due to age-related chromatin condensation