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Roughly 1% to 2% of an oral dose crosses the gut by passive diffusion, no intrinsic factor required

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The CRF 2 shows a wide distribution in the brain, most notably in the amygdala, lateral septum, supraoptic nucleus, ventromedial hypothalamus, dorsal raphe nuclei, area postrema, the nucleus of the solitary tract and the spinal cord (Bittencourt and Sawchenko, 2000