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Endothelial nitric oxide pathway function in the peripheral vasculature of patients with heart failure

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Iron death, characterized by oxidative stress due to intracellular Fe 2+ accumulation, leading to large amounts of ROS production, ultimately results in cell death (161) and contributes to various cardiovascular diseases including atherosclerosis, I/R injury, HF, myocardial infarction and adriamycin cardiomyopathy (162)