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It is possible to increase the LD 50 by 2–4.5 fold when individuals are treated with multiple non-toxic doses beforehand

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[DOI] [PubMed] [Google Scholar] Marino F, Cosentino M, Bombelli R, Ferrari M, Maestroni GJ, Conti A, Lecchini S, Frigo G (1997) Measurement of catecholamines in mouse bone marrow by means of HPLC with electrochemical detection