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Accordingly, loss of SIRT4 enhances glutamine-dependent proliferation and genomic instability, which simultaneously contribute to tumorigenesis 151

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Introduction Over 300 million people suffer from chronic obstructive pulmonary disease (COPD) worldwide (Figure 1), which causes alveolar wall destruction and decreased surface area in the lung parenchyma for gas exchange ( Figure 1 Environmental irritants, especially cigarette smoke, are the main risk factors of emphysema development