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Research gaps and prioritized next steps Key gaps include limited validated pharmacodynamic biomarkers beyond sulforaphane, lack of standardized and stabilized delivery formulations, incomplete mapping of host proteome S-thiolation to define therapeutic windows, inconsistent combination-testing pipelines, and insufficient field data linking agricultural use to resistome outcomes

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reported that ectopic endometriotic implants show reduced expression of key mitophagy proteins, including BNIP3, AMBRA1, and Parkin, which further confirms that mitophagy is suppressed in EESCs (59)