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Although isoform X1 is absent in certain higher organisms, such as mice, elephants, dogs and chickens, it is highly conserved across many other species ( via the inhibition of NOTCH1 signaling

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Additionally, pups of choline-supplemented dams exhibited lymphocytes that produced lower IL-6 and IFN-γ following concanavalin A stimulation, compared to those from the 100% free choline group (87)