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While enriched in NRF2-activated cancer cells, these metabolites were also present at lower levels in cells without NRF2 activation, suggesting that the processes that generate them are operative in normal cellular physiology

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Studies using yeast where the glycolytic enzyme triose phosphate isomerase was deleted showed a reduced NADP + /NADPH ratio likely due to increased PPP flux, but decreased replicative lifespan [82], perhaps in part due to reductive stress