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Conversely, one recent study showed that promoting PI3K signaling by dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl)oxovanadate (BpV), a phosphatase and tensin homolog (PTEN) inhibitor, reversed deficits in both basal turnover and activity-mediated spine stabilization in hippocampal slices, restored defective long-term potentiation (LTP) mechanisms in slices and improved reversal learning in Fmr1 knockout mice (Boda et al., 2014)

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These polyunsaturated fats are critical components of cell membranes throughout the body, and are particularly abundant in the brain