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Conclusion: Novel systemic therapies including Sint-IBI305 and Cam-Rivo demonstrated promising results compared to the current standard regimens (sorafenib, lenvatinib, and Atezo-Bev)

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Additionally, the environmental behavior of nanoparticles warrants attention: they may enter soil and water systems through medical waste or emissions, with the potential to bioaccumulate and move through the food chain, posing possible risks to ecosystems and public health (179, 181)