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DNMT1 is described as the maintenance methyltransferase, while DNMT3a and DNMT3b are de novo methyltransferases ( N -methylation), oxygen ( O -methylation), and carbon ( C -methylation)

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[419] Under our proposal, in alignment with the QPP, if an ACO is affected by an EUC that persists from one performance year to a subsequent performance year, then the ACO would be required to submit a MIPS EUC Exception application for each affected performance year