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Conclusion Since we now found that only a small percentage of CMD patients have abnormal low levels of LH, FSH and/or TSH between lGF-1 levels of 84–100 µ/l, we cautiously propose that IGF-1 low levels may be too low to be considered as an independent diagnostic marker to treat AGHD with CMD patients

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[3] [9] Those with neurological symptoms may require more frequent dosing initially (alternate days until improvement) followed by two-monthly maintenance