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IGF-II levels resulting from LOI are increased and are associated with an increased risk for a variety of cancers including colorectal cancer (15) More recently other mechanisms responsible for elevated levels of IGF-II in colorectal cancer have been identified including microsatellite instability (16)

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For most people: • Mild brightness changes: 6–8 weeks • Noticeable tone improvement: 3–4 months • Maximum visible effects: 6 months or longer Consistency matters more than speed