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DNA constructs Plenti6/V5-DEST plasmids expressing mouse full-length MT1-MMP and its mutants tagged with Flag at the C terminus were a kind gift from Dr

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Its reduction leads to the homology and sharing of bacterial epitopes (such as the mimicins expressed by Clostridium ) with host neural antigens (such as myelin basic proteins), 415 , 416 triggering incorrect recognition by the immune system, promoting cross-reaction of autoantibodies and attacking the CNS