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37,38 In some MDD patients, stress leads to long-term elevated glucocorticoids, resulting in synaptic structural changes and remodeling, and the stress-induced hyperactivity of the HPA axis leads to negative feedback imbalance of the HPA axis, which is also related to depression

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Mol Pharm 4(6):807–818 [DOI] [PubMed] [Google Scholar] Anderson AC, Sullivan JM, Tan DJ, Lee DH, Kuchroo VK (2015) AT cell extrinsic mechanism by which IL-2 dampens Th17 differentiation

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