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Furthermore, since the current literature suggests the high utility of transgenic mouse models in evaluating the role of omega-3-PUFAs in humans, we believe there is potential to transfer these results to human models [144]

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Hibernating Mammals and Metabolic Flexibility Some hibernating mammals, including ground squirrels and bears, exhibit shifts in glucose metabolism during torpor, where alternative pathways like the polyol pathway may contribute to osmotic and metabolic regulation while glucose metabolism slows down