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Keywords: Parkinson’s disease, Vitamin B12, Vitamins, Homocysteine, Motor, Non-motor Introduction Parkinson’s disease (PD) is a multicomplex, multi-neurotransmitter, progressive chronic disease which encompasses not only motor features (such as bradykinesia, rigidity, tremor, and gait disturbance) but also nonmotor features (including constipation, neuropathy, pain, and cognitive decline (Sauerbier et al