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In addition to nonenzymatic glycation, AGEs can be formed through the polyol pathway and lipid peroxidation in the presence and absence of hyperglycemia, depending on the substrate type, reactant concentration, exposure time, and host cellular context 14,15,16,17

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Além disso, pode ter diminuído a expressão de enzimas do ciclo da ureia, possivelmente restaurado o balanço de nitrogênio e, teoricamente, alterado ou melhorado as concentrações de nitrogênio em diferentes órgãos