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Methods: According to reviewing recent literature, we combined evidence from cross-sectional studies, randomized controlled trials, systematic reviews, and meta-analyses, with a center on citing research findings utilizing multimodal neuroimaging techniques (such as fMRI, fNIRS, EEG) and molecular biology techniques to construct a complete chain of evidence from molecules to systems

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The increased level of GSH synthesis and expression of GSTP1 in most types of cancer cells, along with a reversed pH gradient (i.e., a lower extracellular pH of ~6.7–7.1 and a higher intracellular pH of 7.4) [271,272], may influence the rate of S-glutathionylation in the tumors