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Investigating Metabolic Phenotypes for Sarcoidosis Diagnosis and Exploring Immunometabolic Profiles to Unravel Disease Mechanisms

[5] This gene encodes a member of the glutathione peroxidase family

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Nickel can bind to DNA repair enzymes and generate reactive oxygen species, leading to glutathione depletion, which can result in changes in nucleic acids, resulting in mutations in active genes, a critical point in carcinogenesis [103]