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In general, alcohol-containing beverages that are darker in color (e.g., bourbon, red wine) typically have higher congener levels than those lighter in color (e.g., vodka, white wine) and are linked to triggering more pronounced hangover symptoms with more severe headaches (43, 44)

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This activation triggers downstream signaling pathways, leading to the phosphorylation of STAT proteins, thereby regulating the expression of a series of genes and affecting cell function and physiological activity