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The main drawbacks of such methods are the difficulty of achieving cell type-specific profiling if suitable surface markers (that can be targeted by antibodies) are unavailable and, for future applications, the challenge of delivering large antibody reagents and high-intensity light into animals and tissue

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In light of the “amyloid cascade hypothesis” considerable research effort has focused on the accumulation of insoluble brain Aβ protein as a basic cause of AD [47,48]