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It is activated by cytokines and growth factors like IL-6, IFN-γ, and TGF-β, directly influencing HSC transformation and fibrosis severity (Tang et al., 2017

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Taken together, natural polysaccharides reshape gut ecology (beneficial taxa↑, SCFAs↑), reinforce the epithelial barrier (mucus/TJ proteins↑), rebalance mucosal immunity (Tregs↑, NF-κB↓), and mitigate oxidative stress (Nrf2 axis↑)