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Besides bile acids, SCFAs were reported to be related to NSAID enteropathy, long-term use of NSAIDs can obviously decrease the concentrations of SCFAs, such as isobutyrate, isovaleriate, and L-lactate in the elderly, meanwhile the proportion of acetate, propionate, and butyrate were also reduced although not statistically significant, thereby destroying the normal energy supply of intestinal epithelial cells (Tiihonen et al., 2008)