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28 Mitapivat did not significantly impact 2,3-DPG or hemoglobin levels but did further increase ATP levels and decrease spleen size, leukocytosis, RBC reactive oxygen species levels, and RBC mitochondrial retention in HbSS mice, suggesting potential beneficial mechanisms apart from inhibition of HbS polymerization by reducing 2,3-DPG

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However, we recommend taking them with a meal containing vitamin C (to promote the absorption of collagen)