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Relapse occurs in part due to the redox-induced dedifferentiation of non-GSCs that would add to this therapy resistance (Bao et al., Quite a few other mechanisms could be responsible, including OS, which would modulate the efficacy of treatments and resistance in various ways, impacting on drug sensitivity, apoptosis, angiogenesis, or inflammatory pathways (Nathan and Cunningham-Bussel, It has been shown that, during chemotherapy, tumor cells could overcome drug-induced OS by enhancing their antioxidant systems as well as an increasing P-gp pump efflux to acquire a new redox balance due the increased ROS accumulation and antioxidant systems in a process of redox rearranging (see Figure 1)