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Treatment regimen ranges from localized therapies for cutaneous lesions to systemic, often toxic approaches for DCL, ML, and VL ( Leishmania parasites to evade the host immune response and persist despite treatment has prompted a reevaluation of current therapeutic strategies ( Leishmania exploits some host metabolic pathways such as arginine, thiol, and polyamine syntheses to thrive in the hostile environment of the host macrophages