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doi: 10.1016/j.bbr.2016.03.010

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[0315] The third rat ID infusion study was performed to compare bioavailability of stabilized peptides MEDI7219 (SEQ ID NO:2) and SEQ ID NO:6 with that of semaglutide, H-His-Aib- Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu- Glu-Gly-Gln-Ala-Ala-Lys(AEEAc- AEEAc-y-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly- OH (SEQ ID NO: 11) , (Novo Nordisk), an un-stabilized GLP-1 peptide analog, that only has Aib in its sequence for protection from circulating DPP-IV peptidases, (Table 7 and FIG