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Key Takeaways: Semaglutide Side Effects Nausea is the most common side effect, affecting 30% to 44% of people Most side effects are gastrointestinal: nausea, diarrhea, constipation, vomiting Side effects typically peak within days of dose increases, then improve over 1 to 3 weeks Starting at low doses and increasing gradually minimizes side effect intensity Most side effects are manageable with dietary adjustments and timing strategies Serious side effects are rare but include pancreatitis, gallbladder problems, and kidney issues Side effects usually improve significantly after 2 to 3 weeks at each dose Many people experience no significant side effects at all Most Common Side Effects and Their Frequency Understanding what you’re likely to encounter helps you prepare and recognize that your experience is normal