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The interaction between NRF2 and KEAP1 can also be disrupted by somatic mutations of the NFE2L2 and KEAP1 genes, as observed in carcinomas of the lung (123, 147, 150, 153, 190), gallbladder (146), ovary (84), breast (119, 152), stomach, liver (190), skin, larynx, and esophagus (77)