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COP1 contains four distinct domains: an N-terminal Glycine/Serine (G/S) rich domain, a RING domain which interacts with E2 ubiquitin-conjugating enzymes

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MAPK pathways regulate cardiomyocyte proliferation, stress responses, and inflammatory gene expression, while the PI3K/Akt pathway contributes to endothelial nitric oxide production, cell survival, and the inhibition of apoptosis [17,18]