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One mechanism of resistance to IGF-1R or erbB targeted therapy occurs by the heterodimerization of IGF-1R with erbB receptors [52, 53], which provides an alternative signaling pathway to activate downstream mediators of cell proliferation and survival (Figure 2)

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CrossRef Development and temporal external validation of a high-specificity XGBoost rule-in model for diabetes in middle-aged and older Korean adults Soo Myeong Kim, Jung Min Cho Diabetology & Metabolic Syndrome.2026;[Epub] CrossRef Trends in prescribing sodium‐glucose cotransporter 2 inhibitors for individuals with type 2 diabetes with and without cardiovascular‐renal disease in South Korea, 2015–2021 Kyoung Hwa Ha, Soyoung Shin, EunJi Na, Dae Jung Kim Journal of Diabetes Investigation.2025