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It is well known that intestinal disbiosis is a key element in the pathogenesis of various diseases, not only affecting the intestines, but also other organs

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Choi et al., 2016, reported that piceatannol (a resveratrol metabolite found in red wine) affected HDAC expression in a mouse model and concluded that it may be a valuable therapeutic agent in renal fibrosis by decreasing HDAC4 and HDAC5 protein expression [264]