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Depending on the target material, this can include the use of detergent or other buffers, proteinases or other enzymes, heating to various times/temperatures, or mechanical disruption such as cutting with a knife or homogenizer, using a mortar and pestle, or bead-beating with a bead mill

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The importance of Keap1 in the repression of Nrf2 has been demonstrated clearly by its knockout in the mouse [245] and its knockdown in human cell lines [246]