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67 Bisaga et al enrolled 378 patients with OUD with the goal of starting XR-NTX, randomized to 3 arms: naltrexone with buprenorphine, naltrexone with placebo buprenorphine, and placebo naltrexone with placebo buprenorphine

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Furthermore, a randomized cohort study 21 years after the start of the pivotal interferon-beta 1b trial reported that the hazard rate of death was reduced by 46.8% among patients treated with interferon-beta 1b 250 mcg compared with placebo (40)

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