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4 Phytochemicals and phytoextracts modulating the L-arginine/NO/cGMP/K ATP pathway for the treatment of metabolic disorders By improving endothelial function, increasing NO bioavailability, and exerting antioxidant effects, phytochemicals can provide a complementary approach to conventional therapies and ultimately help improve health outcomes in metabolic diseases (Figure 2)

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160 and (6) other diseases, such as Rowell’s syndrome, 161 macular rash, 162 and chilblain-like lesions 163 (Fig