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Exposure to R-1507, a mAb directed against IGF-1R, downregulated the nucleotide excision repair pathway in human small cell lung cancer (SCLC) cell lines and induced chemo- and radio-sensitization to cisplatin/ionizing radiation in selected SCLC models [32]

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This reactivity is the main reason of the cytotoxicity in all cells exposed to acrolein [5] which limits using CP in clinical practice