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[ref] The rare mutations that cause early-onset Alzheimer’s cause the astrocytes to have reduced expression of EAAT2.[ref] The rare mutations in the LRRK2 gene that cause familial Parkinson’s also interact with EAAT2 expression in glial cells.[ref] Related article : APOE and Alzheimer’s disease | Parkinson’s genetic susceptibility Epilepsy: The glutamate transporters are responsible for keeping glutamate low, and thus, they play an important role in epilepsy

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[DOI] [PubMed] [Google Scholar] 71.Wiggenlinkhuizen M., Tilanus M.E.C., Bollen C.W